Cannelloni or Manicotti? What do you call it? The only real difference is that Manicotti is made with preformed pasta tubes and Cannelloni is made with rectangular pasta sheets or crepes. Back in my gluten-eating days, I made Manicotti quite often, loved it! I have yet to find gluten-free Manicotti shells, so I chose to make Cannelloni with Heartland Oven Ready Lasagna. I smothered them in a savory bechamel sauce instead of the typical tomato sauce. It turned out amazing!